Multicomponent Synthesis of Functionalized 2-Amino-4H-pyrans Initiated by the Knoevenagel Reaction

The multicomponent condensation of aldehydes, malononitrile derivatives, 1,3-dicarbonyl compounds of the carbo- and heterocyclic series, and alkyl halides has been studied. The transformation is initiated by the Knoevenagel reaction and leads to the formation of functionally substituted fused 2-amino-4H-pyrans. The structure of a few products was studied by X-ray diffraction (XRD) analysis.