Влияние вспомогательных веществ на технологические характеристики таблетированной лекарственной формы

На примере экспериментальных композиций таблеток глибенкламида 5 мг, пролонгированного действия, полученных прямым прессованием, рассмотрено влияние наполнителей кальция гидрофосфата дигидрата, микрокристаллической целлюлозы и лактозы моногидрата на сыпучесть и прессуемость таблетируемой массы.

EFFECT OF EXCIPIENTS ON THE TECHNOLOGICAL CHARACTERISTICS OF TABLET FORMULATIONS

Excipients exert a substantial effect on the technological characteristics of tablet formulation. The cold pressing technology that is most sensitive to the primary properties of the raw materials used has strict requirements for parameters, such as friability (flowability), compressibility, particle shape and size. By using the experimental compositions of extended-release 5-mg glibenclamide tablets, which had been obtained by direct compression, as an example, the authors considered the effect of the excipients calcium hydrogen phosphate dihydrate, microcrystalline cellulose, and lactose monohydrate on the friability and compressibility of tableted mass. The experiment has demonstrated that the substitution of lactose monohydrate for a combination of microcrystalline cellulose and calcium hydrogen phosphate dihydrate results in the preparation of tablets of equivalent strength, by making much lower efforts.