A Bright Future for Immunotherapy: CAR T-Cell Therapy Promises Revolutionary Changes

Chimeric antigen receptor (CAR) T-cell therapy is an innovative technology that has fundamentally changed approaches to treating certain forms of oncological diseases. The anticipated development of CAR T cell-based therapies in the near future is expected to broaden the range of therapeutic targets and holds the potential to decrease treatment costs, thereby expanding accessibility for a broader patient population. This review article provides an overview of the practical applications of CAR T-cell therapy in clinical settings, describes the global market for commercial CAR T-cell products and offers insights into the future landscape of CAR T-cell therapy. We focus on emerging therapies, novel targets and strategic approaches to improve treatment efficacy and reduce costs. Furthermore, we discuss the progress of CAR T-cell therapy in Russia, where this type of therapy is in the early stages of development but already demonstrates promising potential.

Авторы
Rybachuk V.A. 1 , Evstratova E.S. 1 , Klabukov I.D. 1 , Ivanov S.A. 1 , Shegai P.V. 1 , Kaprin A.D. 1, 2 , Baranovsky D.S. 1, 2, 3
Издательство
Mediscience GmbH
Номер выпуска
22
Язык
English
Страницы
71-84
Статус
Published
Год
2024
Организации
  • 1 National Medical Research Radiological Center, Moscow, Russia
  • 2 Peoples' Friendship University of Russia, Moscow, Russia
  • 3 Russian University of Medicine of the Ministry of Health of the Russian Federation, Moscow, Russia
Ключевые слова
hematological malignancies; adoptive immunotherapy; chimeric antigen receptor (CAR); CAR T-cell therapy
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