The Study of Dentine Matrix Metalloproteinases (Mmps) Activity in Devitalized Teeth

The goal of this study was the need to update the chlorhexidine adhesive protocol in the treatment of devital teeth in the presence of TIMP1 and TIMP2 in fragments of removed teeth previously endodontically treated and removed according to indications using PCR. The study was conducted on 38 human molars removed according to indications, which were divided into 2 groups: 1 group of the studied samples – 22 removed devital molars and 2 group – the control group - these are 16 third molars removed according to orthodontic indications. The removed teeth of each group were fragmented using a diamond-coated disk and air-water cooling. According to the results it was found that MMP 2 and MMP 9 are contained not only in vital, but also in devital teeth. The use of a chlorhexidine adhesive Protocol is relevant in both clinical cases but depending on the type of MMP and the state of the pulp the concentration of chlorhexidine is selected © 2023, Journal of International Dental and Medical Research.All Rights Reserved.