KIM-1 and Other Markers of Acute Kidney Injury in Cisplatin-Induced Nephrotoxicity; [KIM-1 и другие маркеры острого повреждения почек при цисплатин-индуцированной нефротоксичности]

Nephrotoxicity is one of the main dose-limiting factors for cisplatin in anticancer chemotherapy. The limitations of traditional indicators of renal function, such as blood creatinine and urea nitrogen, encourage the search for new informative markers that allow early diagnosis of cisplatin-induced nephrotoxicity in order to properly maintain kidney health and timely correct the treatment plan. This review provides a general description of biomarkers of acute kidney injury (AKI), which have received special attention in this aspect today. Experimental and clinical data from recent years regarding these indicators in cisplatin-induced AKI are presented, with an emphasis on one of the most promising biomarkers, kidney injury molecule 1 (KIM-1). © 2024 Vita e Pensiero. All rights reserved.