Synthesis and three-dimensional structures of substituted 4-silyl-4-piperidols

1,2 5-Trimethyl-4-(methyldiphenylsilyl)- and 4-(dimethylphenyl)silyl-4-piperidols were obtained. The isomers of these piperidols of the γ series, which exist in the chair conformation, have all of their substituents, except the hydroxyl group, equatorially oriented. The isomers of the α series exist in solution in the form of an equilibrium mixture of chair and boat conformations, and all of the substituents, except the silyl grouping, are equatorially oriented in the chair conformation. © 1977 Plenum Publishing Corporation.