A simple, three-component synthesis of 2-aminothiazoles using trimethylsilyl isothiocyanate

The first multicomponent, solution-phase protocol to prepare privileged 2-aminothiazoles from α-bromocarbonyl compounds and amines (aromatic and aliphatic) using commercially available trimethylsilyl isothiocyanate is described. © 2013 Elsevier Ltd. All rights reserved.

Авторы
Golubev V. 1 , Zubkov F. 1 , Krasavin M. 2
Journal
Tetrahedron Letters
Издательство
Elsevier Ltd
Номер выпуска
36
Язык
English
Страницы
4844-4847
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1016/J.TETLET.2013.06.102
Том
54
Год
2013
Организации
  • 1 Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, Russian Federation
  • 2 Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia
Ключевые слова
Combinatorial chemistry; 2-Aminothioazoles; Multicomponent reactions; Parallel solution-phase synthesis; Privileged structures
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