Modified method for the synthesis of isomeric N-substituted (1H-pyrazolyl)propane-1,3-diones

The condensation reaction of isomeric N-substituted (1H-pyrazol-4-yl) ethanones with the ethyl esters of pyrazole carboxylic acids and fluoroacetic acids has been studied using NaH as the base. Under optimized conditions, it proved to be a convenient and preparative method for the synthesis of N-substituted (1H-pyrazolyl)propane-1,3-diones and (1H-pyrazolyl)-4- polyfluorobutane-1,3-diones. © 2011 Springer Science+Business Media, Inc.