EXPERIENCE OF MYO-INOSITOL USE IN PATIENTS WITH OLIGOMENORRHEA AND INSULIN RESISTANCE

Oligomenorrhea (OM) is a menstrual disorder that can be associated with various causes including disorders of carbohydrate and fat metabolism. One of the manifestations of impaired carbohydrate metabolism is insulin resistance (IR) which leads to hyperinsulinemia. Excess insulin stimulates the adrenal glands and results in hyperandrogenism, which in turn reduces the sensitivity of estrogen-dependent ovarian receptors to insulin. This condition is further complicated by polycystic ovary syndrome. Objective: To study the effect of administration of myo-inositol (MI) in combination with alpha-lactalbumin (α-LA) on the length of the menstrual cycle and the rate of carbohydrate metabolism in women with OM and IR. Materials and methods: An observational study included 30 reproductive-aged patients of with OM and IR, who were administered a three-month course of treatment with the Inofert Forte complex containing MI 600 mg + α-LA + folic acid 200 mcg. The patients were evaluated for the clinical, anamnestic and anthropometric data, bioimpedance analysis of body composition, and the results of an oral glucose tolerance test (OGTT) with insulin before and after the course of therapy. Results: After the course of treatment with a combination of MI + α-LA, the length of the menstrual cycle became normal in 13/22 (59.1%) patients and was 34.2 (1.0) days in these women. The average length of the menstrual cycle was 38.4 (1.9) days (p<0.001). A decrease in fasting glucose levels was found in 16/30 (53.3%) patients, in 20/30 (66.7%) patients after one hour and in 30/30 (100%) patients after two hours (Δ0.66±0.35, p<0.001). A decrease in fasting insulin levels was noted in 19/30 (63.3%) of the examined patients two hours after OGTT (p<0.04). Conclusion: The addition of the complex containing MI 600 mg + α-LA + folic acid 200 mcg (Inofert Forte) to the therapy of patients with OM and IR may have a positive effect on the menstrual cycle and may improve metabolic parameters. © 2025 Elsevier B.V., All rights reserved.