Functional Features of Senescent Cells and Implications for Therapy

Cellular senescence is a key mechanism of aging. Senescent cells negatively affect the function of tissues and organs, significantly contributimg to the aging of the organism. Functional and structural characteristics of senescent cells, such as genomic changes and cell cycle arrest, lysosome and mitochondrial dysfunction, and production of SASP factors, are promising therapeutic targets in the context of healthy longevity. The present review was designed to characterize the features of senescent cells in order to discuss current methods and problems of geroprotective therapy and perspective factors for the development of new strategies of anti-aging treatment. Publications were searched based on the analysis of articles containing the keywords “senescent cells, aging, senolytic therapy, SASP, mitochondrial dysfunction” in the PubMed and Scopus databases up to March 2025. © 2025 Elsevier B.V., All rights reserved.

Авторы
Kirichenko Tatiana V. 1, 2 , Markina Yuliya V. 1, 2 , Markin Alexander M. 1, 2, 3 , Vasilyev Vyacheslav S. 4 , Hua Huiming 5, 6 , Li Dahong 5, 6 , Woo Anthony Y.H. 7 , Deev Roman V. 1, 2 , Eremin Ilya I. 1, 2 , Kotenko Konstantin V. 1, 2
Journal
International Journal of Molecular Sciences
Издательство
Molecular Diversity Preservation International
Номер выпуска
11
Язык
English
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.3390/IJMS26115390
Номер
5390
Том
26
Год
2025
Организации
  • 1 Petrovsky National Research Centre of Surgery, Moscow, Russian Federation
  • 2 Petrovsky Medical University, Moscow, Russian Federation
  • 3 Medical Institute, RUDN University, Moscow, Russian Federation
  • 4 Institute of Plastic Surgery and Cosmetology, Moscow, Russian Federation
  • 5 Shenyang Pharmaceutical University, Shenyang, China
  • 6 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
  • 7 School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China
Ключевые слова
aging; mitochondrial dysfunction; SASP; senescent cells; senolytic therapy
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