Общество с ограниченной ответственностью Издательско-торговая корпорация "Дашков и К". 2018. 411 с.
Bioactive coatings with antibacterial effects for internal osteosynthesis
This article presents results from studies of experimental samples with bioactive coatings manufactured by micro-arc oxidation followed by application of a composite coating based on a bioresorbable polymer (chitosan) supplemented with a pharmaceutical preparation (povidone-iodine, octenidine dihydrochloride). Study samples were found to suppress the activity of hospital strains of microorganisms to different extents. The test samples did not have marked toxic properties in relation to human mesenchymal stem cells and were able to induce them to undergo osteogenic differentiation. The results obtained form this set of studies proposed optimal types of coatings for intraosseous titanium implants with antibacterial properties for clinical testing at the N. N. Burdenko Main Military Clinical Hospital, Ministry of Defense of the Russian Federation. © 2025 Elsevier B.V., All rights reserved.
Авторы
Kozelskaya Anna I. 1 , Goreninskii Semen I. 2, 3 , Verzunova Ksenia N. 1 , Dorozhko Elena V. 4 , Bakina Olga Vladimirovna 5 , Buldakov Michael A. 6 , Choynzonov E.L. 6 , Brizhan Leonid K. 7, 8 , Kerimov Artur A. 9 , Khominets Igor V. 9 , Nelin N.I. 7 , Davydov D.V. 7, 10, 11 , Tverdokhlebov Sergei Ivanovich 1
Journal
Издательство
Springer New York Consultants Bureau
Номер выпуска
1
Язык
English
Страницы
65-70
Статус
Published
Ссылка
Том
59
Год
2025
Организации
- 1 Weinberg Research Center, Tomsk Polytechnic University, Tomsk, Russian Federation
- 2 Research Center for Translational Medicine, Sirius University of Science and Technology, Sochi, Russian Federation
- 3 Additive Technologies Center, Tomsk Polytechnic University, Tomsk, Russian Federation
- 4 Division for Chemical Engineering, Tomsk Polytechnic University, Tomsk, Russian Federation
- 5 Laboratory of Nanobioengineering, Institute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, Tomsk, Russian Federation
- 6 Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation
- 7 Main Military Clinical Hospital named after Academician N. N. Burdenko of the Ministry of Defense of the Russian Federation, Moscow, Russian Federation
- 8 Ministry of Health of Russian Federation, Moscow, Russian Federation
- 9 Center for Traumatology and Orthopedics, Main Military Clinical Hospital named after Academician N. N. Burdenko of the Ministry of Defense of the Russian Federation, Moscow, Russian Federation
- 10 Russian Federation Ministry of Defence, Moscow, Russian Federation
- 11 RUDN University, Moscow, Russian Federation
Ключевые слова
Cell culture; Hospitals; Plastic coatings; Polymeric implants; Titanium; Antibacterial effects; Bioactive coatings; Bioresorbable polymers; Composites coating; Microarc oxidation; Osteosynthesis; Pharmaceutical preparations; Study samples; Test samples; Toxic properties; Composite coatings; chitosan; iodine; octenidine; povidone iodine; vanadium; antibacterial activity; antibacterial coating; Article; biological activity; cell adhesion; controlled study; cytotoxicity; electrochemical analysis; energy dispersive X ray spectroscopy; enzyme activity; high performance liquid chromatography; mesenchymal stem cell; nonhuman; particle size; physical chemistry; scanning electron microscopy; spectrophotometry; ultraviolet spectroscopy; voltammetry; X ray diffraction; zone of inhibition
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Другие записи
Neuroscience and Behavioral Physiology. Том 55. 2025. С. 743-746