Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety

We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φfl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers. © 2024 Elsevier B.V., All rights reserved.

Авторы
Uspenskaya Anastasia A. 1 , Doroshenko Irina A. 1 , Popovicheva Kseniia A. 2 , Shmychkov Nazar V. 1 , Pryakhina Ekaterina V. 3 , Shafikov Radik R. 1, 4 , Skvortsov Dmitry A. 4 , Beklemishev Mikhail K. 1 , Zaborova Olga V. 1 , Podrugina Tatyana A. 1 , Machulkin Alexey E. 1, 5 , Beloglazkina Elena K. 1
Journal
Bioorganic and Medicinal Chemistry Letters
Издательство
Elsevier Ltd
Язык
English
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1016/J.BMCL.2024.130025
Номер
130025
Том
115
Год
2025
Организации
  • 1 Department of Chemistry, Lomonosov Moscow State University, Moscow, Russian Federation
  • 2 Faculty of Fundamental Physical and Chemical Engineering, Lomonosov Moscow State University, Moscow, Russian Federation
  • 3 Faculty of Biology and Biotechnology, HSE University, Moscow, Russian Federation
  • 4 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation
  • 5 Department of Biochemistry, RUDN University, Moscow, Russian Federation
Ключевые слова
Asymmetric carbocyanine; Click reaction; Cyanine dyes; Photochemistry
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