Prevalence, demographics, and clinical characteristics of nephroptosis in kyrgyzstan: A three-year retrospective study

Nephroptosis (NP), which is marked by excessive movement of the kidneys, has attracted renewed attention due to advancements in imaging technology. This retrospective study aimed to determine the prevalence, demographics, and clinical characteristics ofNP in Kyrgyzstan using ultrasound Doppler examinations. Data from 13,235 patients at the Salymbekov University Clinic Network were analyzed over a period of three years. NP was detected in 378 (2.9%), with a higher prevalence in females (79.4%) than in males (20.6%). The most affected age group was 20-40 years (58.5%), and right-sided NP predominated (75.1%). The number of NP cases increased annually, suggesting improved detection or changing trends. Comorbidities were found present in 57.9% of patients, with lupus nephritis (LN) being the most common (16.4%). Multivariate logistic regression analysis indicated that sex was not a significant predictor of LN in patients with NP. Immunosuppressive therapy with prednisone and cyclophosphamide improved kidney function in patients with NP and LN, although persistent symptoms required additional management or surgery in some cases. This highlights the importance of early detection and multidisciplinary management of NP. This study provides insights into the epidemiological patterns and clinical implications ofNP in Kyrgyzstan, emphasizing the need for targeted screening, standardized diagnostic criteria, and preventive strategies for high-risk groups. © 2025 Elsevier B.V., All rights reserved.