Objective. To evaluate the effectiveness of repeated breast reconstruction in cancer patients depending on complications after primary reconstruction. Material and methods. There were 117 patients who underwent primary one-stage breast reconstruction with endoprosthesis, autograft and/or their combination. Results. A retrospective analysis included 117 patients who underwent complex treatment in 2017—2021. Surgical treatment (subcutaneous/skin-sparing mastectomy with one-stage reconstruction) was realized at the department of oncology and reconstructive surgery of the breast and skin. Analysis included patients after one-stage reconstruction with silicone endoprosthesis (n=96, 82%), different flaps (n=3, 2.5%), combination of auto- and allogenic materials (n=18, 15.3%). The most common complications were Backer grade III/IV capsular contracture, implant rupture, endoprosthesis protrusion and flap necrosis. The most preferable redo surgery was implant-to-implant replacement (n=58). Of these, there were 40 (68.9%) redo surgeries for Backer grade III/IV capsular contracture, implant protrusion (n=7, 12%) and rupture (n=5, 8.6%). Flap necrosis required flap replacement with implant, flap reduction and implant placement under the flap. Conclusion. Each technique has certain advantages and disadvantages, and the choice of method depends on individual characteristics of each patient. © 2025 Elsevier B.V., All rights reserved.