Cardiovascular diseases are the focus of attention for both scientists and practitioners in medicine due to their leading contribution to premature mortality. In recent years, numerous studies have been published showing gender differences in diagnostic parameters, drug reactions, and the course and outcomes of cardiovascular diseases. However, current guidelines for their diagnosis and treatment do not indicate the need for a gender-differentiated approach to patient care. Since differences in pathology are rooted in differences in healthy organisms, we conducted a study of young healthy individuals (163 men and 181 women) aged 18 to 25 years to identify gender differences in hemodynamic parameters. The examination was performed using a hardware and software complex that allows for the calculation of twenty hemodynamic parameters using non-invasive oscillometric blood pressure measurement. Processing of anonymized research results using descriptive and multidimensional statistical methods showed the presence of significant differences both in individual parameters and in their overall patterns between gender-based groups. The obtained results allow us to speak about the need for further research in order to develop a gender approach to improve the efficiency of diagnostics and treatment of hemodynamic disorders. © 2025 Elsevier B.V., All rights reserved.