According to the concept of quality of life in patients with bone tumors, quality of life is integral characteristic of person’s well–being in conditions of severe musculoskeletal disease with vital threat, reflecting person’s ability to live an active life, be involved in professional activities, take part in family and social affairs, i.e. personality adaptation during and after treatment. Quality of life in patients with this pathology is significantly reduced due to disease and therapy, which is often severe and prolonged, which requires the use interdisciplinary approach to therapy and comprehensive psychosocial rehabilitation. Rehabilitation of patients with bone tumors of extremities after organpreserving surgery, which is currently considered as priority surgical procedure providing local tumor control, involves two types of measures: restorative (aimed at returning to independence from outside help in everyday life) and supportive (aimed at restoring partial independence from outside help in everyday activities and improving the quality of life). One of the key components of early postoperative rehabilitation is formation of patient’s confidence in the possibility of independent activity and understanding of its necessity. Comprehensive rehabilitation of patients after lower limb amputation plays a major role in restoring functions, makes it possible to return to self-care, work, and activity. It is important that independence from outsiders in everyday life, achieved during rehabilitation, significantly correlates with higher level of 6-month survival. The article considers various approaches to psychosocial rehabilitation of patients with bone tumors of the extremities after organ-preserving surgery and patients who have undergone amputations, emphasizing the importance of timely rehabilitation measures. © 2025 Elsevier B.V., All rights reserved.