A new method has been proposed for the treatment of gunshot wounds complicated by nosocomial microflora. The method is based on the treatment of wounds with high-intensity pulsed optical radiation of a continuous spectrum in the wavelength range from 200 to 1100 nm. A pulsed xenon lamp is used as a radiation source. The effect of high-intensity pulsed wide-spectrum optical radiation and low-intensity continuous UV radiation with a maximum at a wavelength of 272 nm and a half-width of the spectrum of 12 nm on the course of the wound process in a gunshot injury was compared. It has been shown that the effect of such radiation on tissues with signs of purulent-inflammatory process provides an antibacterial effect and stimulates tissue regeneration. At the same time, high-intensity wide-spectral optical radiation has a more pronounced anti-inflammatory effect and contributes to the earlier development of tissue regeneration compared with low-intensity narrow-spectrum UV radiation. However, the use of high-intensity optical radiation requires an individual dosage for each phase of the wound process. © 2025 Elsevier B.V., All rights reserved.