Diffuse telogen effluvium: Etiology, pathogenesis, and a comprehensive approach to treatment; Диффузная телогеновая алопеция: этиология, патогенез, комплексный подход к лечению

Diffuse telogen alopecia is a common condition characterized by temporary hair loss due to the premature transition of hair follicles into the telogen phase. This article examines the key etiological factors, pathogenetic mechanisms, and modern approaches to the diagnosis and treatment of this condition. Diffuse telogen alopecia can develop as a result of physiological processes such as pregnancy and the postpartum period, as well as due to pathological conditions. Special attention is given to the impact of stress factors, infectious diseases, endocrine dysfunctions, severe systemic illnesses, metabolic disorders, micro-nutrient deficiencies, and adverse drug reactions on the onset and progression of this condition. Identifying triggering factors is crucial for determining an effective treatment strategy. The diagnosis of diffuse telogen alopecia requires a comprehensive approach, including a detailed medical history, clinical examination, trichoscopy, and laboratory investigations aimed at identifying potential causes of hair loss. The treatment of diffuse telogen alopecia is multidisciplinary and focuses on eliminating the primary causative factor, normalizing metabolic processes, regulating the nervous and endocrine systems, improving scalp microcirculation, and stimulating hair growth. This article discusses the application of a therapeutic system consisting of specialized cosmetic products and a pharmaceutical preparation containing active natural ingredients that contribute to achieving stable therapeutic results. The composition of these agents and their pharmacodynamic mechanisms for enhancing scalp microcirculation and restoring the metabolic activity of hair follicles are analyzed in detail. The effectiveness of a comprehensive treatment approach is demonstrated through a clinical case of successful management of post-infectious diffuse telogen alopecia in a 10-year-old boy. © 2025 Elsevier B.V., All rights reserved.