Aim — to study the effectiveness of using the foam form of 3% sodium tetradecyl sulfate in the treatment of patients with venous malformations of the maxillofacial region. Materials and methods. The study included 30 patients with venous malformations of the maxillofacial region. Patients were divided into three groups: Group 1 — patients with small malformations up to 2 cm in diameter; Group 2 — patients with medium malformations from 2 cm to 6 cm in diameter; Group 3 — patients with large malformations from 6 cm in diameter. Foam form of 3% sodium tetradecyl sulfate was used for sclerotherapy. Results. According to the study, large malformations decreased in size by an average of 49.7±17.8%, medium malformations decreased by an average of 68.1±19.2%, while small malformations decreased by 69.6±18.2%. Conclusion. Sclerotherapy of venous malformations of the maxillofacial region with foam form of 3% sodium tetradecyl sulfate is an effective, easily accessible and safe method of treatment. © 2025 Elsevier B.V., All rights reserved.