The Effect of Dental Implant Nanotopography on its Osseointegration

To determine the relationship between nanotopography of dental implants and its osseointegration. Consider the main methods of creating nanotopographic surfaces and compare different types of surfaces and evaluate their effectiveness in accelerating cellular processes. Materials and methods. The study of up-to-date information from the PubMed, Google Scholar, and ResearchGate electronic databases was carried out during a systematic review of the literature. Selected and included articles, the content of which concerns the influence of various cellular reactions, nanotopography of implants, their coating and manufacturing technology. 57 articles were reviewed. After analyzing the literature for inclusion criteria, the total number of publications has become 50. Conclusion. Studies have demonstrated that implants with specific nanotopographical patterns and coatings enhance cell adhesion, proliferation, and differentiation, all crucial factors in the osseointegration process. These intricate surfaces promote optimal interactions between osteoblasts and the implant, facilitating the deposition of bone matrix and improving the overall stability of the implant within the alveolar bone. Moreover, the presence of nanoscale roughness can play a vital role in modulating the inflammatory response, which is essential for healing. A well-designed nanotopography may lead to a more favorable wound healing environment, reducing the risk of complications such as infection or implant rejection. As a result, dentists and oral surgeons are increasingly considering surface modifications that provide enhanced mechanical interlocking and biological response, ultimately leading to a higher success rate of dental implants. © 2025 Elsevier B.V., All rights reserved.