Obesity: proliferative risk and the possibility of overcoming it

Obesity still remains a global and most urgent problem of the world’s public health system. Exponential growth of incidence all over the world has encouraged the World Health Organization (WHO) to declare that obesity is a global non-communicable pandemic of the 21st century. In the recent decades, a rapid increase in the prevalence of overweight and obesity that are inevitably associated with carcinogenic risk, including proliferative disorders (hyperplasia) and endometrial cancer, is reported globally. The today’s epidemiological data demonstrate that there is a strong correlation between obesity and endometrial hyperplasia (EH), which represent the associated clinical conditions based on many parameters (specifically, pathogenetic). The paper reports pathogenetic associations between obesity and EH, as well as modern strategies to overcome those based on the national and new international guidelines (2025). © 2025 Elsevier B.V., All rights reserved.