EPIGENETIC ABNORMALITIES AND NEUROENDOCRINE DIFFERENTIATION IN PROSTATE CANCER

Objective. Unlike genetic changes, epigenetic aberrations in prostate cancer can be reversed under the influence of a chemical agent. This fact makes the study of epigenetic changes an important object as potential therapeutic targets. Material and Methods. PubMed, Medline, eLibrary.ru databases were analyzed for the keywords: epigenetic prostate cancer, lineage plasticity, neuroendocrine differentiation. For this literature review, 84 relevant publications were selected. The review included studies from 1982 to 2024. Results. The most widely studied epigenetic mutations are DNA hypo-and hypermethylation, histone variability (methylation and acetylation), and neuroendocrine differentiation. Conclusion. The study of the genomic landscape can reveal new opportunities for improving the diagnosis and therapy of castration-resistant prostate cancer (CRPC), which is a potentially lethal form of the disease. It is important not only to search for new biomarkers to identify genetic disorders, but also to study the optimal therapy for advanced prostate cancer. © 2025 Elsevier B.V., All rights reserved.

Авторы
Kovchenko Grigori A. 1 , Sivkov Andrey V. 2 , Lyubchenko Lyudmila N. 3 , Kaprin Andrey D. 4, 5, 6
Journal
Сибирский онкологический журнал
Издательство
Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук"
Номер выпуска
1
Язык
Russian
Страницы
115-124
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.21294/1814-4861-2025-24-1-115-124
Том
24
Год
2025
Организации
  • 1 Innovation Department, N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Moscow, Russian Federation
  • 2 N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Moscow, Russian Federation
  • 3 Department of Molecular Genetics and Cell Technologies, N.A. Lopatkin Research Institute of Urology and Interventional Radiology, Moscow, Russian Federation
  • 4 RUDN University, Moscow, Russian Federation
  • 5 P. A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation
  • 6 A. Tsyb Medical Radiological Research Center, Obninsk, Russian Federation
Ключевые слова
lineage plasticity; neuroendocrine differentiation; prostate cancer epigenetics
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