Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB

The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression. © Springer Science+Business Media, Inc. 2007.

Авторы
Kalinina E.V. 2, 3 , Chernov N.N. 3 , Saprin A.N. 1 , Kotova Ya.N. 1 , Gavrilova Yu.A. 1 , Chermnykh N.S. 1 , Shcherbak N.P. 1
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
3
Язык
English
Страницы
301-303
Статус
Published
Том
144
Год
2007
Организации
  • 1 Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Russian Federation
  • 2 Institute of Cytochemistry and Molecular Pharmacology, Moscow, Russian Federation
  • 3 Peoples’ Friendship University of Russia
Ключевые слова
Doxorubicin; Drug resistance; Thioredoxin
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