Doxorubicin-related cardiotoxicity: review of fundamental pathways of cardiovascular system injury

Over the years, advancements in the field of oncology have made remarkable strides in enhancing the efficacy of medical care for patients with cancer. These modernizations have resulted in prolonged survival and improved the quality of life for these patients. However, this progress has also been accompanied by escalation in mortality rates associated with anthracycline chemotherapy. Anthracyclines, which are known for their potent antitumor properties, are notorious for their substantial cardiotoxic potential. Remarkably, even after 6 decades of research, a conclusive solution to protect the cardiovascular system against doxorubicin-induced damage has not yet been established. A comprehensive understanding of the pathophysiological processes driving cardiotoxicity combined with targeted research is crucial for developing innovative cardioprotective strategies. This review seeks to explain the mechanisms responsible for structural and functional alterations in doxorubicin-induced cardiomyopathy. © 2024 Elsevier B.V., All rights reserved.

Авторы
Avagimyan Ashot A. 1 , Pogosova Nana 2, 3 , Kakturskiy Lev V. 4 , Sheibani Mohammad 5, 6 , Challa Abhiram 7 , Kogan Evgeniya Aleksandrovna 8 , Fogacci Federica 9 , Mikhaleva Liudmila M. 4 , Vandysheva Rositsa A. 4 , Yakubovskaya Marianna Gennadievna 10, 11 , Faggiano Andrea 12, 13 , Carugo Stefano 12, 13 , Urazova O.I. 14 , Jahanbin Behnaz 15 , Lesovaya Ekaterina A. 10, 11, 16 , Polana Srujana 17 , Kirsanov Kirill I. 10, 11 , Sattar Yasar 7 , Trofimenko Artem I. 18 , Demura T.A. 8 , Saghazadeh Amene 15 , Koliakos George G. 19 , Shafie Davood 20 , Alizadehasl Azin Com 21 , Cicero Arrigo F.G. 22, 23 , Costabel Juan Pablo 24 , Biondi-Zoccai Giuseppe 25, 26 , Ottaviani Giulia 27 , Sarrafzadegan Nizal S. 28, 29
Journal
Cardiovascular Pathology
Издательство
Elsevier Inc.
Язык
English
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1016/J.CARPATH.2024.107683
Номер
107683
Том
73
Год
2024
Организации
  • 1 Department of Internal Desiases Propedeutics, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
  • 2 Deputy Director of Research and Preventive Cardiology, National Medical Research Centre of Cardiology named after Academician E.I. Chazov, Moscow, Russian Federation
  • 3 Head of Evidence-Based Medicine Department, RUDN University, Moscow, Russian Federation
  • 4 Research Institute of Human Morphology, Russian Academy of Medical Science, Moscow, Russian Federation
  • 5 Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran
  • 6 IUMS Razi Drug Research Center, Tehran, Iran
  • 7 Department of Cardiology, West Virginia University, Morgantown, United States
  • 8 Institute of Clinical Morphology and Digital Pathology, Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 9 Atherosclerosis and Metabolic Disorders Research Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy
  • 10 Chemical Cancerogenesis Department, National Medical Research Center for Oncology named after N. N. Blokhin, Moscow, Russian Federation
  • 11 Laboratory of Single Cell Biology, RUDN University, Moscow, Russian Federation
  • 12 Department of Cardio-Thoracic-Vascular Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
  • 13 Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy
  • 14 Department of Pathophysiology, Siberian State Medical University, Tomsk, Russian Federation
  • 15 Department of Pathology, Imam Khomeini Hospital, Tehran, Iran
  • 16 Department of Oncology, Ryazan State Medical University, Ryazan, Russian Federation
  • 17 Jawaharlal Nehru Medical College Belgaum, Belagavi, India
  • 18 Department of Pathophysiology, Kuban State Medical Academy, Krasnodar, Russian Federation
  • 19 Laboratory of Biological Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • 20 Director of Heart Failure Centre, Isfahan Cardiovascular Research Center, Isfahan UMS, Isfahan, Iran
  • 21 Rajaie Cardio-Oncology Research Center, Tehran, Iran
  • 22 Hypertension and Cardiovascular Risk Research Unit, Alma Mater Studiorum Università di Bologna, Bologna, Italy
  • 23 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
  • 24 Chief of Coronary Care Unit, Technological Institute of Buenos Aires, Buenos Aires, Argentina
  • 25 Department of Medical-Surgical Sciences and Biotechnologies, Sapienza Università di Roma, Rome, Italy
  • 26 Maria Cecilia Hospital, Cotignola, Italy
  • 27 Department of Biomedical, Università degli Studi di Milano, Milan, Italy
  • 28 Isfahan Cardiovascular Research Center, Isfahan UMS, Isfahan, Iran
  • 29 School of Population and Public Health, University of British Columbia, Faculty of Medicine, Vancouver, Canada
Ключевые слова
Cardio-oncology; Cardiotoxicity; Chemotherapy; Doxorubicin
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