Общество с ограниченной ответственностью Издательско-торговая корпорация "Дашков и К". 2018. 411 с.
Lupus nephritis and thrombotic microangiopathy: A review
Lupus nephritis (LN) is one of the most common organ-specific manifestations of systemic lupus erythematosus (SLE). Various clinical signs of LN develop in at least 50% of patients with SLE. In addition to LN, the spectrum of renal lesions associated with SLE also includes vascular pathology. One of the variants of renal microvascular injury is thrombotic microangiopathy (TMA), the mechanisms of which are diverse. The review focuses on the main forms of TMA, including antiphospholipid syndrome and nephropathy associated with antiphospholipid syndrome, TMA caused by complement system regulation disorders and deficiency of ADAMTS13. In most cases, these forms of TMA are combined with LN. However, they may also exist as a single form of kidney damage. This article discusses the TMA pathogenesis, the impact on kidney prognosis, and treatment options.
Авторы
Bobrova L.A. 1 , Kozlovskaya N.L. 2, 3
Journal
Издательство
Общество с ограниченной ответственностью Медицинское маркетинговое агентство МедиаМедика
Номер выпуска
6
Язык
Russian
Страницы
628-634
Статус
Published
Том
96
Год
2024
Организации
- 1 Sechenov Univ, Sechenov First Moscow State Med Univ, Moscow, Russia
- 2 Patrice Lumumba Peoples Friendship Univ Russia, Moscow, Russia
- 3 Yeramishantsev City Clin Hosp, Moscow, Russia
Ключевые слова
lupus nephritis; thrombotic microangiopathy
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