Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms

A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Авторы
Afanasyev O.I. 1 , Zarochintsev A. 2 , Petrushina T. 2 , Cherkasova A. 2 , Denisov G. 1 , Cherkashchenko I. 3 , Chusova O. 4 , Jinho O. 5 , Man-Seog C. 5 , Usanov D.L. 6 , Semenov S.E. 2 , Chusov D. 1
Journal
European Journal of Organic Chemistry
Номер выпуска
1
Язык
English
Страницы
32-35
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1002/EJOC.201801412
Том
2019
Год
2019
Организации
  • 1 Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova St. 28, Moscow, 119991, Russian Federation
  • 2 Moscow South-Eastern School named after V.I. Chuikov (Moscow Chemical Lyceum), Tamozhenniy proezd 4, Moscow, 111033, Russian Federation
  • 3 Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1, Moscow, 119991, Russian Federation
  • 4 Faculty of Science, RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 5 Korea Science Academy of KAIST, 105-47, Baegyanggwanmun-ro, Busanjin-gu, Busan, 614-822, South Korea
  • 6 Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, United States
Ключевые слова
Aldehydes; Carbonyl ligands; CO surrogate; Iron carbonyl; Nitrile; Reduction; Reductive alkylation
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