Methionine gamma lyase from clostridium sporogenes increases the anticancer efficacy of doxorubicin on A549 cancer cells in vitro and human cancer xenografts

The anticancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer cells in vitro and in vivo. Doxorubicin (DOX) and MGL were more effective on A549 human lung-cancer growth inhibition than either agent alone in vitro and in vivo. © Springer Science+Business Media, LLC, part of Springer Nature 2019.

Авторы
Pokrovsky V.S. 2, 1 , Anisimova N.Y. 1 , Davydov D.Z. 1 , Bazhenov S.V. 4, 3 , Bulushova N.V. 3 , Zavilgelsky G.B. 3 , Kotova V.Y. 3 , Manukhov I.V. 3, 4
Collection of articles
Methods in Molecular Biology
Издательство
Humana Press Inc.
Язык
English
Страницы
243-261
Статус
Published
DOI
10.1007/978-1-4939-8796-2_18
Том
1866
Год
2019
Организации
  • 1 Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Moscow, Russian Federation
  • 2 Department of Biochemistry, People’s Friendship University (RUDN University), Moscow, Russian Federation
  • 3 State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russian Federation
  • 4 Laboratory of Molecular Genetics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russian Federation
Ключевые слова
Anticancer efficacy; Clostridium sporogenes; Doxorubicin; Human tumor xenografts; Lung cancer; Methioninase
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