Rational design of an efficient one-pot synthesis of 6H-pyrrolo[2,3,4- gh] perimidines in polyphosphoric acid

Several highly efficient one-pot synthetic protocols were developed, enabling polyphosphoric acid-activated nitroalkanes to act as electrophiles in reactions with aminonapthalenes. The featured methods allow for the single step assembly of polyheterocyclic aromatic derivatives of 6H-pyrrolo[2,3,4-gh]perimidine scaffold in high yields. © 2016 The Royal Society of Chemistry.