Direct reductive coupling of indoles to nitrostyrenes en route to (indol-3-yl)acetamides

A highly efficient one-pot method for the reductive coupling of indoles to nitrostyrenes in polyphosphoric acid doped with PCl3 was developed. This method allows direct and expeditious access to primary (indol-3-yl)acetamides, interesting as anti-cancer drug candidates. © 2016 The Royal Society of Chemistry.

Авторы
Aksenov A.V. 1 , Aksenov N.A. 1, 2 , Dzhandigova Z.V. 1 , Aksenov D.A. 1 , Voskressensky L.G. 2 , Nenajdenko V.G. 3 , Rubin M. 4, 1
Journal
RSC Advances
Номер выпуска
96
Язык
English
Страницы
93881-93886
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1039/C6RA21399E
Том
6
Год
2016
Организации
  • 1 Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol, 355009, Russian Federation
  • 2 Department of Organic Chemistry, People's Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 3 Department of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russian Federation
  • 4 Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582, United States
Ключевые слова
Anticancer drug; En-route; One-pot method; Polyphosphoric acids; Reductive couplings
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