ctDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer

BACKGROUND. Transrenal cell-free tumor DNA (TR-ctDNA), which transits from the bloodstream into urine, has the potential to enable noninvasive cancer detection for a wide variety of nonurologic cancer types.

Авторы
Bhambhani Chandan 1 , Kang Qing 1 , Hovelson D.H. 2, 3 , Sandford Erin 1 , Olesnavich Mary 1 , Dermody S.M. 4 , Wolfgang Jenny 1 , Tuck K.L. 1 , Brummel Collin 4 , Bhangale A.D. 4 , He Kuang 1 , Gutierrez M.G. 5 , Lindstrom R.H. 1 , Liu Chia-Jen 3, 6 , Tuck Melissa 1 , Kandarpa Malathi 1 , Mierzwa Michelle 7, 8 , Casper Keith 4, 8 , Prince M.E. 4, 8 , Krauss J.C. 1 , Talpaz Moshe 1 , Henry N.L. 1, 8 , Giraldez M.D. 1, 9 , Ramnath Nithya 1 , Tomlins S.A. 3, 6, 10 , Swiecicki P.L. 1, 8 , Brenner J.C. 4, 8, 11 , Tewari Muneesh 1, 8, 12, 13
Journal
JCI Insight
Номер выпуска
6
Язык
English
Статус
Published
Том
9
Год
2024
Организации
  • 1 Department of Internal Medicine, Division of Hematology/Oncology,
  • 2 Department of Computational Medicine & Bioinformatics,
  • 3 Michigan Center for Translational Pathology,
  • 4 Department of Otolaryngology,
  • 5 Department of Internal Medicine,
  • 6 Department of Pathology,
  • 7 Department of Radiation Oncology, and
  • 8 Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
  • 9 Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, University of Seville, Seville, Spain.
  • 10 Department of Urology,
  • 11 Department of Pharmacology,
  • 12 Center for Computational Biology and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • 13 Department of Biomedical Engineering, and
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