Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields. © 2017 The Royal Society of Chemistry.

Авторы
Zhao Y. 3 , Sharma U.K. 1 , Schröder F. 1 , Sharma N. 1 , Song G. 3 , Van Der Eycken E.V.
Journal
RSC Advances
Номер выпуска
52
Язык
English
Страницы
32559-32563
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1039/C7RA06004A
Том
7
Год
2017
Организации
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, KU Leuven, Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 2 Peoples Friendship University of Russia, RUDN University, 6 Miklukho-Maklaya street, Moscow, 117198, Russian Federation
  • 3 Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai, 200237, China
Ключевые слова
Activation analysis; Acylation; Catalysis; Toluene; Acyl source; C-h activation; Pivalic acid; Tert-butylhydroperoxide; Palladium compounds
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