Synthesis and in vitro antifungal activity of selenium-containing chitin derivatives

Mild and ‘green’ ultrasound-assisted reaction of chitin with 3-(chloromethyl)[1,2,4]selenadiazolo[4,5-a]pyridin-4-ium bromide in water affords novel selenium-containing cationic chitin derivatives. The thus obtained chitin derivatives are water soluble and are characterized by high in vitro antifungal activity comparable with conventional antifungal drug Amphotericin B. © 2022

Авторы
Egorov A.R. 1 , Yagafarov N.Z. 2, 1 , Artemjev A.A. 1 , Khubiev O. 1 , Medjbour B. 1 , Kozyrev V.A. 1 , Donovan Sikaona N. , Tsvetkova O.I. 1 , Rubanik V.V. 3 , Kurliuk A.V. 4 , Shakola T.V. 4 , Lobanov N.N. 1 , Kritchenkov I.S. 3, 1, 5 , Tskhovrebov A.G. 1 , Kirichuk A.A. 1 , Khrustalev V.N. 1, 6 , Kritchenkov A.S. 3, 1
Journal
Mendeleev Communications
Издательство
Royal Society of Chemistry
Номер выпуска
3
Язык
English
Страницы
357-359
Статус
Published
Ссылка
Внешняя ссылка
DOI
10.1016/J.MENCOM.2022.05.022
Том
32
Год
2022
Организации
  • 1 Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
  • 2 N. I. Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
  • 3 Institute of Technical Acoustics, National Academy of Sciences of Belarus, Vitebsk, 210009, Belarus
  • 4 Vitebsk State Medical University, Vitebsk, 210009, Belarus
  • 5 St. Petersburg State University, St. Petersburg, 199034, Russian Federation
  • 6 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Ключевые слова
alkylation; antifungal activity; chitin; organoselenium compounds; ultrasound; [1,2,4]selenadiazolo[4,5-a]pyridin-4-ium salts
Цитировать
ГОСТ MLA RIS BibTex
Поделиться

Другие записи