Biodistribution of 213Bi–Metallothionein and 213Bi–IgG in Intact Mice

Abstract One of the important problems of radiopharmaceutics is the development of new approaches for the creation of radiopharmaceuticals based on antibodies while maintaining their specificity and affinity for antigens. The metal-binding protein metallothionein is proposed as a chelator for the α-emitting 213Bi radionuclide. The results of studying the biodistribution of 213Bi–metallothionein (213Bi–MT), 213Bi–immunoglobulin (213Bi–IgG), and unconjugated 213Bi in the form of 213BiCl3 in intact mice are presented.