A FACILE AND STEREOSELECTIVE APPROACH TO SUBSTITUTED POLYAMINES

Spermidine and norspermidine polyamine derivatives are synthesized in two or three steps by sodium borohydride reduction of substituted 2-(2-cyanoethyl)- and 2-(2-benzylaminoethyl)-1.2-dihydropyrimidines, respectively; these diazines are in turn available from 4-amino-1-azadiene derivatives 1.