Synthesis of Polyalkoxymethylenedioxy-1,4-naphthoquinones from Parsley Seed\r\nMetabolite

A convenient synthesis of polyalkoxy-1,4-naphthoquinones, good starting materials\r\nfor analogues of natural quinones, has been developed. Bromonaphthoquinone, more\r\nstable than its hydroxylated analogue, turned out to be a convenient and accessible key\r\nsynthon for the preparation of various polyalkoxylated naphthoquinones. The obtained quinones\r\ncould be useful starting materials for the preparation of biologically active polymethoxy-\r\nand hydroxy-methylenedioxynaphthoquinones.