6-Exo-dig cyclization/dearomatization cascade towards N–O fused spiro polyheterocycles
A hypervalent iodine-mediated cascade cyclization of alkyne-tethered N-alkoxybenzamides for the construction of structurally novel N–O fused spiro polyheterocycles was developed.
1 Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China
2 Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, B-3001 Leuven, Belgium
3 Peoples’ Friendship University of Russia (RUDN University), Moscow 117198, Russia