Антитела к оболочечным белкам Е1 и Е2 у людей, инфицированных вирусом гепатита С

Antibodies of envelope proteins E1 and E2 in patients with acute and chronic hepatitis С

This research aimed to study humoral response against immunodominant B-epitopes of envelope proteins E1 and E2 in patients with acute and chronic hepatitis С and in human with resolution of acute infection. Specific antibodies were revealed by enzyme-linked immunosorbent assay with 8 synthetic peptides modeling immun- odominant B-epitopes of envelope proteins as immunosorbents. It has been discovered that majority of patients with acute and chronic hepatitis С have antibodies to these epitopes, but resolved human do not display them. Association between the outcome of acute HCV infection and the presence of antibodies to B-epitopes has not been revealed. In chronic hepatitis С antibodies to C-terminal B-epitope of HVR1 were revealed reliably more often than in acute hepatitis С