Psychopharmacotherapy and psychotherapy methods are used for psychopathological conditions in neurological patients. The experience of psy-chopharmacotherapy combined or not combined with psychotherapy in 242 patients with neurological disorders is reported. Beneficial effects of psychopharmacotherapy are observed in 70.1% of cases, while that of psychopharmacotherapy combined with psychotherapy are reported in 78.0% of cases. The data on efficacy and tolerability of a number of psychotropic agents are provided. It has been shown that the use of psy-chotropic agents and psychotherapy results in the reduced rate of exacerbation of neurological disorders, reduces the rate of visits to neurologist. Optimization of psychopharmacotherapy and psychotherapy in patients with nervous system disorders is discussed. © 2023, LLC MMA MediaMedika. All rights reserved.