Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts

Diabetes mellitus (DM) is considered by many the pandemic of the 21st century and is associated with multiple organ damages. Among these, cardiovascular complications are responsible for an incredible burden of mortality and morbidity in Western Countries. The study of the pathological mechanisms responsible for the cardiovascular complications in DM patients is key for the development of new therapeutic strategies. The metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia, results in a cascade of pathomorphological changes favoring the atherosclerotic process and leading to myocardial remodeling. Parallel to this, oxidative stress, calcium overload, mitochondrial dysfunction, activation of protein kinase C signaling pathways, myocardial lipomatosis, and low-grade inflammation of the myocardium - are the main pathways responsible for the diabetic cardiomyopathy development. This review aims to appraise and discuss the pathogenetic mechanisms behind the diabetic cardiomyopathy development. © 2023 Elsevier Inc.

Авторы
Avagimyan A. , Fogacci F. , Pogosova N. , Kakrurskiy L. , Kogan E. , Urazova O. , Kobalava Z. , Mikhaleva L. , Vandysheva R. , Zarina G. , Trofimenko A. , Navasardyan G. , Mkrtchyan L. , Galli M. , Jndoyan Z. , Aznauryan A. , Saahakyan K. , Agati L. , Shafie D. , Cicero A. , Di Salvo G. , Sarrafzadegan N.
Журнал
Current Problems in Cardiology
Издательство
Elsevier Inc.
Номер выпуска
1
Язык
Английский
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1016/J.CPCARDIOL.2023.102052
Номер
102052
Том
49
Год
2024
Организации
  • 1 Anatomical Pathology and Clinical Morphology Department, Yerevan State Medical University, Yerevan, Armenia
  • 2 Atherosclerosis and Metabolic Disorders Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
  • 3 Research and Preventive Cardiology, National Medical Research Centre of Cardiology, Moscow, Russian Federation
  • 4 A.P. Avtsyn Research Institute of Human Morphology FSBI “Petrovskiy NRCS” Moscow, Russian Federation
  • 5 Pathology Department, Immunohistochemistry Reference Centre of Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 6 Pathophysiology Department, Siberian State Medical University, Tomsk, Russian Federation
  • 7 Internal Disease and Cardiology Department, Peoples Friendship University of Russia, Moscow, Russian Federation
  • 8 Pathophysiology Department, Kuban State Medical University, Krasnodar, Russian Federation
  • 9 Pathophysiology Department, Yerevan State Medical University, Yerevan, Armenia
  • 10 Cardiology Department, Yerevan State Medical University, Yerevan, Armenia
  • 11 Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy
  • 12 Internal Diseases Propaedeutic Department, Yerevan State Medical University, Yerevan, Armenia
  • 13 Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  • 14 Cardiology Department, Azienda Umberto I, Sapienza University, Rome, Italy
  • 15 Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran
  • 16 Imperial College of London, London, United Kingdom
  • 17 Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Ключевые слова
Diabetes Mellitus; Diabetic Cardiomyopathies; Humans; Myocardium; Oxidative Stress; Signal Transduction; ketone body; peroxisome proliferator activated receptor; protein kinase C; sodium glucose cotransporter 2; atherosclerosis; calcium overload; causal attribution; diabetic cardiomyopathy; disease course; disorders of mitochondrial functions; dyslipidemia; endoplasmic reticulum stress; endothelium lesion; enzyme activation; glycemic control; human; hyperglycemia; inflammation; insulin dependent diabetes mellitus; insulin resistance; lipomatosis; metal poisoning; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; perivascular adipose tissue; protein expression; protein function; Review; signal transduction; trend study; cardiac muscle; diabetes mellitus; diabetic cardiomyopathy; metabolism
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