Synthesis of 4-amino-substituted tetrahydropyrimido[4,5-d]azocines

A method for the preparation of 4-amino-substituted tetrahydropyrimido[4,5- d]azocines containing an aromatic pyrimidine fragment has been developed. It was established that tetrahydropyrido[4,3-d]pyri-midines are cleaved by the action of activated alkynes with the formation of 6-vinylpyrimidines. © 2013 Springer Science+Business Media New York.