CLINICAL-IMMUNOLOGICAL FEATURES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME

Hemorrhagic fever with renal syndrome (HFRS) is a feral herd disease caused by hantaviruses which manifesta- tions include hemorrhages and renal disorder. HFRS may be severe. Disease severity is generally tailored to im- mune mechanisms. The role of innate lymphocytes, i.e., NK cells and NKT, still remains elusive. Our study dem- onstrated that T helper cell blood count decreases in HFRS while the number of NKT and regulatory T cells in- creases. Severe HFRS develops under functional predomination of regulatory T cells, cytotoxic T cells plays the key role while B cells and innate immune cells are less important.