Implants with or without Leukocyte- and Platelet-Rich Fibrin (L-PRF): A Systematic Review on Dental Implant Stability

Background: To examine the impact of applying leukocyte- and platelet-rich fibrin (L-PRF) on the stability of dental implants using implant stability quotient (ISQ) measurements. Methods: A systematic search of the main databases was conducted to source the literature. Studies that met the established inclusion and exclusion criteria were selected for this review. The focus was solely on randomized controlled trials (RCTs) and controlled clinical trials (CCTs). Results: After conducting a comprehensive search, a total of 1984 studies were identified. Following evaluation based on our inclusion and exclusion criteria, a refined selection of 7 studies was chosen for detailed review in this analysis. Conclusions: Our findings indicate that the use of leukocyte- and platelet-rich fibrin (L-PRF) may enhance the stability of implants following surgical procedures. This suggests that L-PRF may accelerate the healing process, reduce the loading time, and improve outcomes for patients undergoing implant surgery, potentially reducing the risk of implant failures and complications. © 2025 Elsevier B.V., All rights reserved.