HEPATOTROPIC THERAPY FOR DRUG-INDUCED LIVER INJURY (EXPERT MEETING)

A joint council of experts in the field of hepatology reviewed the results of experimental and clinical studies evaluating the efficacy of hepatotropic drugs (ademetionine, ursodeoxycholic acid, ornithine, bicyclol, morpholinium tiazotate, phospholipids, a fixed combination of inosine + meglumine + methionine + nicotinamide + succinic acid), glucocorticoids, extracorporeal detoxification methods in drug-induced liver injury (DILI); inclusion of these medications and treatment methods in clinical guidelines in various countries was analyzed. Indications for the use of hepatotropic drugs were formulated depending on the pattern of DILI (hepatocellular, cholestatic, mixed), as well as in some DILI phenotypes. © 2025 Elsevier B.V., All rights reserved.

Авторы
Okovityi Sergey V. 1, 2 , Raikhelson K.L. 2, 3 , Akhmedov Vadim A. 4 , Vologzanina Ludmila G. 5 , Gladkov Oleg A. 6 , Grechishnikova Vasilisa R. 7 , Deeva Tatiana A. 7 , Dolgushina Anastasiya I. 8 , Zharkova Maria S. 7 , Kozlova I.V. 9 , Kondrashina E.A. 2 , Maevskaya Marina V. 7 , Marchenko Nataliya V. 2, 10 , Pazenko Ye V. 2, 3 , Pirogova Irina Yu 11 , Prikhodko Veronika A. 1 , Maria К. (Prashnova) 2 , Tarasova Larisa V. 12 , Khlynov I.B. 13 , Khlynova Olga V. 5
Журнал
Пермский медицинский журнал
Издательство
Пермский государственный медицинский университет им. ак. Е.А. Вагнера
Номер выпуска
3
Язык
Русский
Страницы
58-74
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.17816/PMJ42358-74
Том
42
Год
2025
Организации
  • 1 Saint-Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russian Federation
  • 2 Saint Petersburg State University, Saint Petersburg, Russian Federation
  • 3 Pavlov University, Saint Petersburg, Russian Federation
  • 4 Omsk State Medical University, Omsk, Russian Federation
  • 5 E.A.Vagner Perm State Medical University, Perm, Russian Federation
  • 6 Medical Oncology Center “EVIMED”, Chelyabinsk, Russian Federation
  • 7 Sechenov First Moscow State Medical University, Moscow, Russian Federation
  • 8 South Ural State Medical University, Chelyabinsk, Russian Federation
  • 9 Saratov State Medical University named after V. I. Razumovsky, Saratov, Russian Federation
  • 10 Russian Center for Research in Radiological and Surgical Technologies, Saint Petersburg, Russian Federation
  • 11 RUDN University, Moscow, Russian Federation
  • 12 Chuvash State University, Cheboksary, Russian Federation
  • 13 Ural State Medical University, Yekaterinburg, Russian Federation
Ключевые слова
cholestatic pattern; Drug-induced liver injury; hepatocellular pattern; hepatotoxicity; treatment
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