REVIEW OF CURRENT METHODS OF DIAGNOSIS AND TREATMENT OF LOCALLY ADVANCED UROTHELIAL BLADDER CANCER

Aggressive disease course, recurrences, and deterioration of patients’ quality of life remain significant challenges in the treatment of bladder cancer. Determining the indications for systemic therapy or radical treatment, the early detection, and the optimal timing for initiating adjuvant therapy are all crucial aspects in the management of urothelial carcinoma. The analysis of the literature on changes in diagnostics and therapeutic approaches to urothelial bladder cancer according to disease stage is presented in the article. © 2025 Elsevier B.V., All rights reserved.