Synthesis, crystal structure and Hirshfeld surface analysis of 5-oxo-N-phenyl-3-(thiophen-2-yl)- 2,3,4,5-tetrahydro-[1,10-biphenyl]-4-carboxamide

The asymmetric unit of the title compound, C23H19NO2S, contains two molecules that differ in the conformation of the two carboxamide moieties. In the crystal, intermolecular N - H⋯O hydrogen bonds link the molecules into chains propagating parallel to the c-axis direction. Between the molecules, weak C - H⋯π(ring) interactions are present, whereas π-π interactions are not observed. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions to the crystal packing are from H⋯H (47.6%), H⋯C/C⋯H (33.4%) and H⋯O/O⋯H (11.6%) interactions. Orientational disorder is observed for both thiophene rings. © 2025 Elsevier B.V., All rights reserved.