THE USE OF HYALURONIC ACID IN VULVOVAGINAL ATROPHY IN WOMEN AFTER ANTITUMOR THERAPY

Objective: To analyze the available literature on the use of hyaluronic acid in programs of non-hormonal correction of vulvovaginal disorders associated with antitumor treatment in cancer patients. Materials and methods: The literature search was conducted in the electronic databases, namely PubMed, Scopus, Web of Science, Cochrane Library, ScienceDirect, Embase, PsycINFO using the keywords in Russian and English. The articles were published between 1914 and 2024. Results: The symptoms of genitourinary syndrome of menopause have a long-term negative impact on the quality of life of women who underwent antitumor treatment. Currently, it is important to develop approaches to supportive and restorative therapy for women at risk of developing genitourinary syndrome of menopause. One of the effective methods for correcting this condition in women undergoing oncological rehabilitation is the use of intravaginal preparations containing hyaluronic acid. These preparations significantly reduce the symptoms of vulvovaginal atrophy with efficacy comparable to that of topical estrogens. Besides, they have high safety and do not cause side effects. Conclusion: The analysis of the literature showed the potential for further research into the efficacy and safety of using hyaluronic acid to correct vulvovaginal changes in cancer patients after antitumor therapy, as well as for long-term follow-up. This research could help determine whether it should be included in the standard restorative treatment for these patients. Such an approach could improve the quality of life for this patient group and address a number of psychological and socio-economic issues. © 2025 Elsevier B.V., All rights reserved.