Efficacy and safety of dermal filler based on poly-D,L-lactic acid

Objective. Assessment of the effectiveness, safety and satisfaction of patients and doctors after procedures for the administration of polylactic acid suspension Repart PLA. Material and methods. The study involved 42 patients (37 women and 5 men) aged 32-65 years who underwent double implantation of the Repair PLA filler in the middle and lower thirds of the face with an interval of 2 months according to the established protocol. The condition of the facial skin was assessed before, during and after the course of procedures. Photo documentation and assessment of the skin condition of the face were performed using photo scales. Ultrasound skin scanning, elastometry, and elastography were performed. The GAIS scale was used to analyze the satisfaction of doctors and patients with treatment results. Throughout the study, the safety and tolerability of the procedures were monitored. Results. The positive dynamics of structural changes in the skin was noted after the first procedure, followed by an increase in the clinical effect for all analyzed parameters. After two procedures of administration of the Repart PLA suspension, an improvement in the condition of the middle and lower parts of the face (4 indicators) and skin quality (4 indicators) was observed in 90% of the participants, and this trend continued throughout the follow-up period. 93% of the participants rated the result as “good” and “excellent” after the first procedure and 98% of the participants after the second procedure. Patients noted good tolerability of the procedure, which does not require additional methods of anesthesia. No unpredictable adverse events were detected after the administration of Repart PLA. Conclusion. The filler based on poly-D,L-lactic acid Repart PLA has shown its effectiveness and safety in correcting the involutional changes of the middle and lower thirds of the face. © 2025 Elsevier B.V., All rights reserved.