Ophthalmopathology in Sharpe’s syndrome

This review is devoted to Sharp syndrome, which is an autoimmune disease of connective tissue with mixed signs of several pathologies at once (systemic scleroderma, systemic lupus erythematosus, rheumatoid arthritis, dermato-or poliomyositis). This causes clinical diversity of the clinical picture, so the diagnosis of patients with Sharp syndrome, especially in the early stages of the disease, is a difficult task for clinical practice. In approximately more than half of the cases, over time, transformation into one or another specific nosological form is possible. Eye damage is diagnosed in about a third of patients and is usually an indicator of disease activity. In this case, ophthalmologic manifestations differ and range from relatively “harmless” dry keratoconjunctivitis (which is most often recorded in all diseases included in this syndrome) and episcleritis to severe scleritis and uveitis (from iridocyclitis to panuveitis), as well as retinovasculitis, leading to severe visual impairment. Treatment of Sharp syndrome is reduced to the use of non-steroidal anti-inflammatory drugs and corticosteroids, including pulse therapy, and then basic antirheumatic drugs (immunosuppressants, etc.). © 2025 Elsevier B.V., All rights reserved.