Objective. To assess the quality of sexual function in patients suffering from genitourinary menopausal syndrome. Materials and methods. The prospective study included 51 postmenopausal women with a verified diagnosis of N95.2 Postmenopausal atrophic vaginitis and 30 postmenopausal women without a verified diagnosis of N95.2 as a control group. The inclusion criteria for the study were: postmenopausal women with a verified diagnosis of N95.2, regular sexual activity at least once a week, informed consent of the patient for the study. The following parameters were assessed: average age of the participants, presence of vaginal, urinary and sexual complaints (dyspareunia, dysorgasmia, decreased libido, postcoital bleeding), female sexuality index. Results. The results of the study demonstrate that women suffering from symptoms of genitourinary menopausal syndrome have a low quality of sexual life. Each patient registered at least one complaint associated with sexual dysfunction. Significantly more often a decrease in libido is recorded, which occurs in 58.8% of cases, dyspareunia – in 39.2% of women, postcoital bloody discharge was noted by 27.4% of respondents. The index of female sexuality was 17.2±5.2, which is 2 times lower compared to the indicator in the control group – 34.4±2.4. Conclusion. Genitourinary postmenopausal syndrome has a negative impact on the quality of sexual life, leading to decreased libido, dyspareunia, postcoital bleeding and, as a consequence, leads to decreased satisfaction with sexual life up to the refusal of sexual intercourse. © 2025 Elsevier B.V., All rights reserved.