5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential

New homologues of 5-amino-1,2,4-triazole-3-carboxamide, viz., 5-(w-aminoalkyl)-1,2,4-triazole-3-carboxamides have been synthesized. The intermediate acyloxalamidrazones undergo thermal cyclization to 1,2,4-triazoles with the better yield in the absence of catalyst while in the presence of 10 mol% TsOH the main product is the corresponding 1,3,4-oxadiazole derivative. The obtained compounds have demonstrated various biological properties comparable to those of the nucleoside drug ribavirin. © 2025 Elsevier B.V., All rights reserved.